Lymphoproliferative Diseases

Atypical Lymphoproliferative Diseases.

This review addresses the clinical presentation, pathology, and therapy of several uncommon lymphoid proliferations. Because these lymphoproliferations span the characteristics of reactive polymorphous proliferations to clonal malignant neoplasms, they are often difficult to diagnose and treat effectively. In Section I, Dr. Greiner describes the pathology of the spectrum of atypical lymphoid di...

Immune thrombocytopenia in lymphoproliferative diseases.

We have studied the thrombocytopenia of lymphoproliferative disorders using a measurement of membrane-bound IgG by an antiglobulin consumption assay. Nine patients with chronic lymphocytic leukemia (CLL) and thrombocytopenia had increased membrane-bound IgG. Two patients with non-Hodgkins lymphoma and 1 patient with Hodgkins disease also had thrombocytopenia and increased membrane-bound IgG. Fi...

Neutropenia and G-CSF in lymphoproliferative diseases

BACKGROUND Chemotherapy-induced neutropenia is a major cause of morbidity and mortality. It frequently causes dose reductions or treatment delay, which can be prevented or treated by the administration of granulocyte-colony-stimulating factor (G-CSF). However, a better knowledge of the incidence, day of onset after therapy, and duration of neutropenia is essential to optimize the use of G-CSF. ...

Gene rearrangements and translocations in lymphoproliferative diseases.

By Henrik Griesser, Douglas Tkachuk, Marciano D. Reis, and Tak W. Mak L YMPHOID LEUKEMIAS and malignant lymphomas are neoplasms characterized by the proliferation of cells derived from the lymphoid tissue and its precursors. Like other malignant hematological disorders, the majority of these lymphoid malignancies are of monoclonal origin.’ Although clonality does not necessarily correlate with ...

Autoimmunity, autoimmune diseases and lymphoproliferative disorders.